Otilonium bromide

SKU: orb1308536

Description

Otilonium bromide (SP63) is a spasmolytic agent with antimuscarinic properties. It is widely used in pharmacological research to study gastrointestinal motility disorders, with applications in both in vitro tissue studies and in vivo animal models of irritable bowel syndrome.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 26095-59-0
• MW: 563.57
• Purity: 99.88% (May vary between batches)
• Formula: C₂₉H₄₃BrN₂O₄
• SMILES: C(CCCCCCC)Oc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1.[Br-]
• Target: AChR,Calcium Channel
• Solubility: DMSO:55 mg/mL (97.59 mM)

Bioactivity

• Target IC50:
  mAChR:880 nM
• In Vivo:
  Methazolamide is a carbonic anhydrase inhibitor that inhibits hCA I (Ki: 50 nM), hCA II (Ki: 14 nM) and bCA IV (Ki: 36 nM) isoforms.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SP 63, SP63, SP-63, Calcium Channel, CalciumChannel, Inhibitor, inhibit, Muscarinic acetylcholine receptor, mAChR, Otilonium, Otilonium bromide, Otilonium Bromide, Octylonium, Octylonium bromide, Octylonium Bromide

Compound Identifiers

PubChem CID

72092