Oncrasin-1

SKU: orb1299305

Description

Oncrasin 1 is a potent small-molecule agent that selectively induces apoptosis in human lung cancer cells harboring K-Ras mutations, with activity in the low to sub-micromolar range. It serves as a valuable research tool for studying oncogenic Ras signaling and has demonstrated efficacy in both in vitro cell culture models and in vivo xenograft studies.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 75629-57-1
• MW: 269.726
• Purity: 99.75% (May vary between batches)
• Formula: C₁₆H₁₂ClNO
• SMILES: ClC1=CC=C(CN2C=C(C=O)C3=C2C=CC=C3)C=C1
• Target: Raf,Ras,DNA/RNA Synthesis,Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (7.41 mM);DMSO:43 mg/mL (159.42 mM)

Bioactivity

• In Vivo:
  In vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Oncrasin 1, Oncrasin1, Oncrasin-1, inhibit, K-Ras, Inhibitor, Apoptosis, Ras

Compound Identifiers

PubChem CID

872445