Omadacycline tosylate

SKU: orb1705439

Description

Omadacycline tosylate

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1075240-43-5
• MW: 728.85
• Purity: 98.00% (May vary between batches)
• Formula: C₃₆H₄₈N₄O₁₀S
• SMILES: S(=O)(=O)(O)C1=CC=C(C)C=C1.O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=C(CNCC(C)(C)C)C4O)[H])[H]
• Target: ribosome,Antibiotic,Antibacterial
• Solubility: H2O:10 mg/mL (13.72 mM);DMSO:Soluble

Bioactivity

• In Vivo:
  In the mouse abdominal infection model, a single intravenous injection of Omadacycline tosylate (0.11-18 mg/kg) demonstrated therapeutic effects against Streptococcus pneumoniae, Escherichia coli, and Staphylococcus vitis vinifera. The 50% effective dose (ED₅₀) for Streptococcus pneumoniae ranged from 0.45 mg/kg to 3.39 mg/kg, while the ED₅₀ for Staphylococcus vitis vinifera ranged from 0.30 mg/kg to 1.74 mg/kg. The ED₅₀ for Escherichia coli was 2.02 mg/kg.
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• In Vitro:
  The 90% minimum inhibitory concentrations (MIC₉₀) of omadacycline tosylate against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and beta-hemolytic streptococci are 1.0 μg/ml, 0.25 μg/ml, and 0.5 μg/ml, respectively; its MIC₉₀ against penicillin-resistant Streptococcus pneumoniae (PRSP) and Haemophilus influenzae (H. influenzae) are 0.25 μg/ml and 2.0 μg/ml, respectively . Omadacycline tosylate (10 μM, equivalent to 5.57 μg/ml) inhibits the ligand-binding activity of the M2 subtype of muscarinic acetylcholine receptors (M2 receptors) by 82%. At the same time, it exerts no substantial effect on the M3 subtype of muscarinic receptors (M3 receptors) or nicotinic acetylcholine receptors .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amadacycline tosylate, Omadacycline Tosylate, PTK 0796 tosylate

Compound Identifiers

PubChem CID

54746485