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Olorofim

SKU: orb2901446

Description

Olorofim(F-901318)is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.

Images & Validation

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Key Properties

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CAS Number1928707-56-5
MW498.55
Purity>98% (HPLC)
FormulaC28H27FN6O2
SMILESC(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5
TargetDehydrogenase

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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500 mg
2 mg
$ 880.00
5 mg
$ 1,300.00
10 mg
$ 1,760.00
25 mg
$ 2,490.00
50 mg
$ 3,070.00
100 mg
$ 3,680.00