NS9283

SKU: orb1304978

Description

NS9283 is a selective positive allosteric modulator of the α4β2 nicotinic acetylcholine receptor. Research indicates its application in preclinical studies for investigating mechanisms of ethanol consumption and addiction-related behaviors in vivo.

Research Area

Neuroscience

Key Properties

• CAS Number: 913830-15-6
• MW: 248.24
• Purity: 99.12% (May vary between batches)
• Formula: C₁₄H₈N₄O
• SMILES: C(#N)C=1C=C(C2=NC(=NO2)C=3C=CC=NC3)C=CC1
• Target: AChR
• Solubility: DMSO:3.06 mg/mL (12.33 mM)

Bioactivity

• In Vivo:
  In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion.
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• In Vitro:
  NS9283 increased the potency of varenicline to activate and desensitize α4β2 nAChRs in vitro without affecting other known targets of varenicline.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

nAChR, Nicotinic acetylcholine receptors, Inhibitor, inhibit, NS 9283, NS9283, NS-9283, α4β2 nAChR

Compound Identifiers

PubChem CID

11998180