Nimodipine

SKU: orb1310704

Description

Nimodipine (BAY-e 9736) is a dihydropyridine-class calcium channel antagonist with selective activity on vascular smooth muscle. It is widely used in research to study cerebrovascular function and neuroprotection in models of subarachnoid hemorrhage, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 66085-59-4
• MW: 418.44
• Purity: >98%
• Formula: C₂₁H₂₆N₂O₇
• SMILES: COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 40 mg/ml).

Bioactivity

• In Vivo:
  Nimodipine (5-20 mg/kg, SC) suppresses in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, exhibits to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bay-e 9736

Compound Identifiers

PubChem CID

4497