Nicotredole

SKU: orb1303266

Description

Nicotredole (Tryptamide) is an orally bioavailable small molecule with analgesic and anti-inflammatory properties. Its anti-inflammatory potency is comparable to phenylbutazone, but it demonstrates significantly lower ulcerogenic activity, making it a useful research tool for in vivo pain and inflammation models.

Key Properties

• CAS Number: 29876-14-0
• MW: 265.3098
• Purity: 99.92% (May vary between batches)
• Formula: C₁₆H₁₅N₃O
• SMILES: O=C(NCCC1=CNC2=C1C=CC=C2)C1=CC=CN=C1
• Target: Others
• Solubility: DMSO:25 mg/mL (94.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

• In Vivo:
  Nicotredole exhibits anti-inflammatory properties as evidenced by its effectiveness in reducing carrageenin-induced paw edema in rats. Additionally, it has been shown to counteract pyrogen-induced hyperthermia, offer analgesic benefits, extend hexobarbital-induced sleep duration, and suppress locomotor activities in both rats and mice. Intraperitoneally (i.p.), Nicotredole holds lethal doses (LD50) of 1260 mg/kg for male rats and 1980 mg/kg for male mice, whereas orally (p.o.), its LD50 values are 8.5 g/kg for male rats and 9.3 g/kg for male mice. Administered either orally or intraperitoneally at a dose of 25 mg/kg, Nicotredole is rapidly absorbed and eliminated, with half-lives ranging from 4.92 to 17.5 minutes for absorption and 55.72 to 74.52 minutes for elimination. It achieves maximum concentration (C max) levels of 11-13 μg/cm^3 within 30 minutes, resulting in area under the curve (AUC) values between 21.40 and 27.30 μg•h/cm^3.
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• In Vitro:
  Nicotredole inhibits prostaglandin synthetase activity in an in vitro assay .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Nicotredole, anti-inflammatory, analgesic, ulcerogenic, Tryptamide

Compound Identifiers

PubChem CID

65768