Niclosamide

SKU: orb1224897

Description

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-65-7
• MW: 327.12
• Purity: >98% (HPLC)
• Formula: C₁₃H₈Cl₂N₂O₄
• SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O
• Target: STAT
• Solubility: Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Animal model: Nu+/Nu+ mice injected with NCI-H295R cells. Dosage: 100 mg/kg, 200 mg/kg. Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks. Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
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• In Vitro:
  Cell Viability Assay Cell line: BD140A, SW-13 and NCI-H295R cells. Concentration: 0.6 nM-46 μM Incubation time: Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 μM, 0.15 μM, and 0.53 μM in BD140A, SW-13, and NCI-H295R, respectively. Cell Viability Assay Cell line: Hela cells. Concentration: 0.05-5 μM Incubation time: 24 hours. Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM. Cell Viability Assay Cell line: Vero E6 cells. Concentration: 10 μM. Incubation time: 2 days. Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 178296

Quick Database Links

Gene Symbol

STAT