Nepetin

SKU: orb1297523

Description

Nepetin

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 520-11-6
• MW: 316.26
• Purity: 99.98% (May vary between batches)
• Formula: C₁₆H₁₂O₇
• SMILES: COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
• Target: Calcium Channel,Interleukin,Histamine Receptor
• Solubility: DMSO:140 mg/mL (442.67 mM);10% DMSO+90% Saline:1 mg/mL (3.16 mM)

Bioactivity

• In Vitro:
  Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαμRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαμRI α± chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcαμRI α± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, 6-Methoxyluteolin, Calcium Channel, HistamineReceptor, Histamine Receptor, Inhibitor, inhibit, Nepetin

Compound Identifiers

PubChem CID

5317284