Neohesperidin Dihydrochalcone

SKU: orb1305047

Description

Neohesperidin Dihydrochalcone

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 20702-77-6
• MW: 612.58
• Purity: >99.99% (May vary between batches)
• Formula: C₂₈H₃₆O₁₅
• SMILES: O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)C3=CC(O)=C(C(CCC4=CC(O)=C(OC)C=C4)=O)C(O)=C3
• Target: ROS,Reactive Oxygen Species
• Solubility: DMSO:50 mg/mL (81.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM);Ethanol:100 mg/mL (163.24 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day, demonstrating the compound's safety at significant dosage levels.
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• Cell Research:
  WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Neohesperidin DC, Neohesperidin Dihydrochalcone, NCI-c60764, NHDC, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

30231