Nav1.7-IN-19

SKU: orb3173369

Description

Nav1.7-IN-19 is a potent, selective, and orally active Nav1.7 inhibitor with an IC50 value of 0.49 μM. It shows high selectivity for Nav1.7, exhibiting 312-fold and 662-fold selectivity over Nav1.1 and Nav1.5, respectively, in the inactivated state. Nav1.7-IN-19 weakly inhibits the hERG potassium channel. Additionally, Nav1.7-IN-19 possesses analgesic properties, making it useful for neurological disorder research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3097995-73-5
• MW: 601.87
• Formula: C₂₃H₂₃BrClFN₄O₅S
• SMILES: O=C(N)C(NCCCC1=CC(Cl)=CC=C1OC2=CC(F)=C(C=C2Br)S(=O)(=O)NC3=NOC=C3)C4CC4
• Target: Potassium Channel,Sodium Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Potassium Channel,Sodium Channel