Mutant IDH1-IN-1

SKU: orb1306660

Description

Mutant IDH1-IN-1 is a highly potent small molecule inhibitor targeting the R132H mutant IDH1 enzyme, demonstrating an IC50 value below 0.1 µM. It is a valuable research tool for investigating mutant IDH1-driven mechanisms in cancers such as glioma and AML, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1355326-21-4
• MW: 498.59
• Purity: >99.99% (May vary between batches)
• Formula: C₃₀H₃₁FN₄O₂
• SMILES: Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCCC1
• Target: Isocitrate Dehydrogenase (IDH),Dehydrogenase
• Solubility: DMSO:60 mg/mL (120.34 mM)

Bioactivity

• Target IC50:
  IDH1 (R132H):< 0.1 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isocitrate Dehydrogenase, IsocitrateDehydrogenase(IDH), Isocitrate Dehydrogenase (IDH), IsocitrateDehydrogenase, Mutant IDH1 IN 1, mutant IDH1 R132H, Mutant IDH1IN1, Mutant IDH-1-IN-1, Mutant IDH1-IN-1, IDH, IDH1-IN-1

Compound Identifiers

PubChem CID

89696514