MS417

SKU: orb1308004

Description

MS417

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 916489-36-6
• MW: 414.91
• Purity: 99.88% (May vary between batches)
• Formula: C₂₀H₁₉ClN₄O₂S
• SMILES: COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1
• Target: Epigenetic Reader Domain,HIV Protease
• Solubility: Ethanol:50 mg/mL (120.51 mM)

Bioactivity

• Target IC50:
  CBP-BRD:32.7 μM|BRD4 BD1:30 nM |BRD4 BD2:46 nM
• In Vivo:
  BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-κB, effectively attenuates NF-κB transcriptional activation of proinflammatory genes in kidney cells treated with TNFα or infected by HIV. MS417 ameliorates inflammation and kidney injury in HIV-1 transgenic mice, an animal model for HIVAN.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MS 417, MS417, MS-417, Human immunodeficiency virus, GTPL 7512, GTPL7512, GTPL-7512, Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, HIV Protease, HIVProtease, HIV, BRD4-BD1, BRD4-BD2, BRD4, CBP BRD

Compound Identifiers

PubChem CID

59190723