Moracin P

SKU: orb1684401

Description

Moracin P is a bioactive 2-arylbenzofuran from Mori Cortex Radicis that acts as a potent HIF-1 inhibitor. It exhibits neuroprotective, anti-inflammatory, and antioxidant effects by reducing ROS generation under oxygen-glucose deprivation, making it a valuable tool for ischemia and neuroinflammation research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 102841-46-3
• MW: 326.34
• Purity: 99.34% (May vary between batches)
• Formula: C₁₉H₁₈O₅
• SMILES: O[C@@H]1CC=2C=C3C(=CC2OC1(C)C)OC(=C3)C4=CC(O)=CC(O)=C4
• Target: HIF,ROS,Reactive Oxygen Species,HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:≥ 80 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.13 mM)

Bioactivity

• Target IC50:
  SH-SY5Y cells:10.4μM (EC50)
• In Vitro:
  Moracin P enhances the cell viability of SH-SY5Y cells in a dose-dependent manner with an EC50 value of 10.4 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIF, NO Synthase, Moracin P, ROS

Compound Identifiers

PubChem CID

25208124