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Monomethyl fumarate

SKU: orb1309398

Description

Monomethyl fumarate acts as a potent and selective agonist for the hydroxycarboxylic acid receptor 2 (HCAR2/GPR109A). This small molecule is utilized in research to investigate anti-inflammatory and neuroprotective pathways, with applications in both in vitro cellular assays and in vivo models of autoimmune and neurological diseases.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number2756-87-8
MW130.0987
Purity99.21% (May vary between batches)
FormulaC5H6O4
SMILESCOC(=O)\C=C\C(O)=O
TargetDrug Metabolite,GPCR
SolubilityDMSO:55 mg/mL (422.75 mM);H2O:8 mg/mL (61.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (15.37 mM)

Bioactivity

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In Vitro
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Dimethyl, DMF, DrugMetabolite, Drug Metabolite, neuroprotective, metabolite, Monomethyl fumarate, Monomethyl Fumarate, Monomethyl, inhibit, Inhibitor, HCA2, HCAR2, HM74A, GPR109A, fumarate, retinal, PUMA-G

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Quality Guarantee

Quality Guarantee

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Key Properties

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No computed properties available.

Protocol Information

Available Sizes

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500 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
DispatchUsually dispatched within 5-10 working days
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