Cytomegalovirus(strain AD169) Glycoprotein H/L/O Human Monoclonal Antibody (MALS verified)

SKU: orb2938586

Description

Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.

Research Area

Immunology & Inflammation

Images & Validation

• Reactivity: Mouse

Key Properties

• Host: Human
• Clonality: Monoclonal
• Isotype: Human IgG1 | Human Kappa
• Clone No.: 2B1
• Target: Glycoprotein H & Glycoprotein L & Glycoprotein O/gH & gL & gO (HCMV)
• Source/Expression System: HEK293
• Purity: 0.95
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Glycoprotein H & Glycoprotein L & Glycoprotein O/gH & gL & gO (HCMV)