Moguisteine

SKU: orb1309534

Description

Moguisteine (BBR-2173) is a novel, peripherally-acting non-narcotic antitussive agent. It is utilized in respiratory research to investigate cough suppression mechanisms, with studies demonstrating its efficacy in both in vitro assays and in vivo animal models of experimentally induced cough.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 119637-67-1
• MW: 339.41
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₂₁NO₅S
• SMILES: C(CC(OCC)=O)(=O)N1C(COC2=C(OC)C=CC=C2)SCC1
• Target: Opioid Receptor,Others
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);Ethanol:63 mg/mL (185.62 mM);DMSO:63 mg/mL (185.62 mM)

Bioactivity

• In Vitro:
  Moguisteine is a novel peripheral nonnarcotic antitussive agent that has proved to be as active as codeine in several experimental models of induced cough in guinea-pigs and dogs. It acts neither through the opiate receptors nor on the cough centre, and its action is possibly mediated by the interaction with rapidly adapting irritant receptors along the tracheobronchial tree. In controlled clinical trials, moguisteine has been shown to be safe and to effectively reduce cough associated with such respiratory disorders as acute upper respiratory tract infection, chronic bronchitis, pulmonary fibrosis and malignancies.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BBR 2173, BBR2173, BBR-2173, Moguisteine, inhibit, Inhibitor

Compound Identifiers

PubChem CID

65935