ML-098

SKU: orb1302704

Description

ML-098 (CID-7345532) is a potent and selective small molecule activator of Rab7 GTPase, exhibiting an EC50 of 77.6 nM. It serves as a valuable research tool for investigating late endosome and lysosome biology, autophagy, and cellular trafficking pathways in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 878978-76-8
• MW: 309.3591
• Purity: 99.52% (May vary between batches)
• Formula: C₁₉H₁₉NO₃
• SMILES: CC1=CC=C(C)C(OCCN2C=C(C(O)=O)C3=C2C=CC=C3)=C1
• Target: Ras
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.46 mM);DMSO:117.5 mg/mL (379.82 mM)

Bioactivity

• Target IC50:
  Rab7:77.6 nM (EC50)
• In Vitro:
  ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CID 7345532, CID7345532, CID-7345532, inhibit, ML 098, ML098, ML-098, Inhibitor, Rab7, Ras

Compound Identifiers

PubChem CID

7345532