Methionine

SKU: orb1706139

Description

D-Methionine (MRX-1024) is a chemoprotective agent that also acts as a GABAA receptor agonist, modulating neuronal activity. It is utilized in research areas such as ototoxicity protection and neuropharmacology, with applications in both in vitro assays and in vivo animal models of chemotherapeutic side effects.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 348-67-4
• MW: 149.211
• Purity: 99.93% (May vary between batches)
• Formula: C₅H₁₁NO₂S
• SMILES: CSCC[C@@H](N)C(O)=O
• Target: GABA Receptor,Endogenous Metabolite
• Solubility: H2O:15.7 mg/mL (105.22 mM)

Bioactivity

• In Vivo:
  Administration of Methionine (D-methionine) concurrently with cisplatin results in a cell density of 0.8±0.070 (SEM), which is significantly higher than that observed in rats receiving cisplatin alone (P<0.01), yet comparable to control groups and those treated with D-methionine only (P>0.05). Solo administration of Methionine yields an average cell density of 0.95±0.099 (SEM), also showing no significant difference from controls (P>0.05).
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• In Vitro:
  When human plasma is incubated with Methionine (D-methionine) and CP, a Pt-D-methionine complex forms, regardless of the sequence in which they are added. Initially, an early CP hydrolysis product combines with Methionine to create a 1:1 complex, which subsequently leads to a 2:1 compound over time. These Pt-D-methionine compounds are crucial in how Methionine shields mammalian organisms from CP-induced toxicities.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D-Methionine, MRX 1024, MRX1024, MRX-1024, Methionine, Human Endogenous Metabolite, EndogenousMetabolite, Endogenous Metabolite, GABA Receptor, GABAReceptor

Compound Identifiers

PubChem CID

84815