Meglumine

SKU: orb1224417

Description

Meglumine is an amino sugar derived from sorbitol. It is often used as an excipient in pharmaceuticals and in conjunction with iodinated compounds in contrast media such as diatrizoate meglumine and iodipamide meglumine.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6284-40-8
• MW: 195.21
• Purity: >98% (HPLC)
• Formula: C₇H₁₇NO₅
• SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
• Target: Others
• Solubility: Water: 39 mg/mL (199.78 mM); DMSO: 39 mg/mL (199.78 mM)

Bioactivity

• In Vivo:
  Animal model: Sprague-Dawley rat. Dosage: 25 or 50 mM. Administration: p.o. , dissolve in water. Result: Reduced the isoprostane levels in rats. Animal model: K6/ODC transgenic mice. Dosage: 37.5 mM. Administration: p.o. , dissolve in water. Result: Reduced the number of skin tumors and inhibited tumor growth. Animal model: KK. Cg-Ay/J mice. Dosage: 18 mM. Administration: p.o. , in drinking water. Result: Performed better in a glucose tolerance test. Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
  Read more...
• In Vitro:
  Western blot analysis. Cell line: C2C12 mouse myoblasts. Concentration: 0, 10, 30, 100, 300 mM or 200 mM. Incubation time: 60 min or 0, 10, 30, 60, 120 min. Result: Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-Deoxy-1-(methylamino)-D-glucitol | Iosulamide | N-Methyl-D-glucamine

Quick Database Links

Gene Symbol

Others