MC-Val-Cit-PAB-Auristatin E

SKU: orb1988053

Description

MC-Val-Cit-PAB-Auristatin E is a cleavable linker-payload for constructing antibody-drug conjugates (ADCs). Its auristatin E warhead potently inhibits tubulin polymerization. This compound is widely used in oncology research for developing targeted therapies and has demonstrated antitumor efficacy in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2055896-77-8
• MW: 1287.65
• Formula: C₆₈H₁₀₈N₁₁O₁₃
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H]([N+](CC3=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN4C(=O)C=CC4=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C3)(C)C)C(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Target: Drug-Linker Conjugates for ADC,PROTAC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139035077