Linoleic acid

SKU: orb1302374

Description

Linoleic acid

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60-33-3
• MW: 280.45
• Purity: 99.61% (May vary between batches)
• Formula: C₁₈H₃₂O₂
• SMILES: C(C/C=C\C/C=C\CCCCC)CCCCCC(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO:55 mg/mL (196.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.33 mg/mL (15.44 mM)

Bioactivity

• Target IC50:
  CHO cells:1.8 μM (EC50)|CHO-K1 cells:0.54 μM (EC50)|RBL-2H3 cells:> 50 μM|HEK293 cells:4.8 μM (EC50)
• In Vivo:
  METHODS: To study the effects on endocannabinoid (EC) biology, four groups of C57BL/6 mice were fed diets containing 1% or 8% Linoleic acid (with or without G (LAG)) for eight weeks. RESULTS: Increasing dietary Linoleic acid from 1% to 8% significantly increased circulatory, small intestinal, and hepatic ECS. 1% LAG-fed mice had the lowest feed efficiencies, and hepatic levels of only two ECs were reduced by the addition of G.
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• In Vitro:
  METHODS: Bovine satellite cell BSCs were treated with Linoleic acid (10-250 µM) for 24-48 h. Cell viability was measured by MTT assay. RESULTS: At 24 h of treatment with Linoleic acid, cell proliferation increased at doses of 10-100 µM and decreased at 250 µM as compared to untreated control. 100 µM Linoleic acid at 48 h had no significant effect on cell proliferation. METHODS: Human ovarian cancer cells SKOV-3 were treated with Linoleic acid (16 µM) for 24 h. Cell migration was detected by wound-healing assay. RESULTS: The average migration in the Linoleic acid treated group increased by about 20% on average compared to control untreated cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arachidonic acid, acidelinoleique, acid, 9,12-Linoleic acid, 9,12-octadecadienoic acid, Inhibitor, human, Endogenous Metabolite, EndogenousMetabolite, endogenous, fatty, essential, nutrient, omega-6, oils, metabolite, inhibit, Linoleic acid, plant, polyunsaturated

Compound Identifiers

PubChem CID

5280450