Licoflavone A

SKU: orb1684466

Description

Licoflavone A is a flavonoid compound isolated from Glycyrrhiza uralensis (licorice) roots. Research indicates it exhibits anti-inflammatory and antioxidant activities, making it a candidate for study in models of metabolic and inflammatory diseases in both cellular and animal systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 61153-77-3
• MW: 322.35
• Purity: 99.93% (May vary between batches)
• Formula: C₂₀H₁₈O₄
• SMILES: CC(C)=CCc1cc2c(cc1O)oc(cc2=O)-c1ccc(O)cc1
• Target: Phosphatase
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:100 mg/mL (310.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.41 mM)

Bioactivity

• Target IC50:
  PTP1B:54.5 μM
• In Vitro:
  Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), glycyrrhisoflavone (4), glisoflavone (5), cycloglycyrrhisoflavone (6), isoliquiritigenin (7), Licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Licoflavone A, Inhibitor, Phosphatase, PTP1B

Compound Identifiers

PubChem CID

5319000