Lauric Acid

SKU: orb1300388

Description

Lauric acid (Dodecanoic acid) is a saturated 12-carbon medium-chain fatty acid naturally abundant in coconut and palm kernel oils. It is widely used in research for studying lipid metabolism, antimicrobial properties, and its effects in both in vitro cellular models and in vivo nutritional studies.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 143-07-7
• MW: 200.3178
• Purity: 99.95% (May vary between batches)
• Formula: C₁₂H₂₄O₂
• SMILES: CCCCCCCCCCCC(O)=O
• Target: Endogenous Metabolite,Antibacterial
• Solubility: H2O:16 mg/mL (79.87 mM);DMSO:260 mg/mL (1297.92 mM);Ethanol:38 mg/mL (189.7 mM)

Bioactivity

• Target IC50:
  P. acnes:2μg/mL(EC50)|S. aureus:6μg/mL(EC50)|S. epidermidis:4 μg/mL(EC50)
• In Vitro:
  Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS.
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• Cell Research:
  Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 105 and 1.5 × 105 cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO2 and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dodecanoic acid, Dodecylic acid, Bacterial, Lauric Acid, EndogenousMetabolite, Endogenous Metabolite, N-Dodecanoic acid

Compound Identifiers

PubChem CID

3893