Lamotrigine

SKU: orb1310392

Description

Lamotrigine (BW430C) is a small molecule anticonvulsant and mood stabilizer that functions by inhibiting voltage-gated sodium channels, thereby reducing neuronal hyperexcitability. It is widely used in neuroscience research for studying epilepsy and bipolar disorder mechanisms in both in vitro electrophysiology and in vivo animal models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 84057-84-1
• MW: 256.091
• Purity: 99.95% (May vary between batches)
• Formula: C₉H₇Cl₂N₅
• SMILES: NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
• Target: 5-HT Receptor,Sodium Channel,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.81 mM);DMSO:43.33 mg/mL (169.2 mM);Ethanol:2.6 mg/mL (10.15 mM)

Bioactivity

• Target IC50:
  5-HT (rat brain synaptosomes):474 μM|5-HT (human platelets):240 μM
• In Vivo:
  In rat cortical brain tissues cultured with 10 mg/L veratridine, Lamotrigine inhibited the release of glutamate and aspartate (both with an ED50 of 5.38 mg/L) twice as effectively as it inhibited the release of GABA (ED50 of 11.2 mg/L), without affecting the basal release of glutamate. Lamotrigine stabilizes presynaptic neuronal membranes by blocking voltage-dependent sodium channels, thereby preventing the release of excitatory neurotransmitters, especially glutamate and aspartate. It does not induce phencyclidine (PCP)-like central nervous system effects, does not act through direct inhibition of NMDA receptors, and may avoid the adverse effects associated with NMDA blockade.
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• In Vitro:
  Lamotrigine is active in electrically induced EEG after-discharge tests, indicating its ability to counteract simple and complex partial seizures. It demonstrates antiepileptic effects in mice and rats, preventing hind-limb extension induced by both MES (maximal electroshock) and pentylenetetrazole. The peak effects of Lamotrigine occur 1 hour post-administration, with a duration exceeding 24 hours. Intravenous administration of Lamotrigine at doses greater than 5 mg/kg in rats results in a dose-dependent reduction in after-discharge duration.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, BW430C, 5-HT (human platelets), 5-HT (rat brain synaptosomes), 5HTReceptor, 5HT Receptor, inhibit, Na+ channels, Na channels, LTG, Lamotrigine, Lennox-Gastaut syndrome, Inhibitor, focal seizure, epilepsy, tonic-clonic seizure, Sodium Channel, SodiumChannel, seizure

Compound Identifiers

PubChem CID

3878