L-Ornithine

SKU: orb1310337

Description

L-Ornithine is a non-proteinogenic amino acid that serves as a key intermediate in the urea cycle for nitrogen detoxification. Research applications include studying its renoprotective and anti-fatigue properties in metabolic, hepatic, and exercise physiology models, both in vivo and in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70-26-8
• MW: 132.16
• Purity: 99.91% (May vary between batches)
• Formula: C₅H₁₂N₂O₂
• SMILES: NCCC[C@H](N)C(O)=O
• Target: Amino Acids and Derivatives,Endogenous Metabolite,Arginase,Decarboxylase
• Solubility: DMSO:Insoluble;H2O:50 mg/mL (378.33 mM)

Bioactivity

• Target IC50:
  Arginase (bovine):1.02 mM (Ki)
• In Vivo:
  METHODS: To investigate the effect of L-Ornithine on peripheral clock gene expression, mice were orally treated with L-Ornithine (1000 mg/kg) for 3 days. RESULTS: The phase of PER2 gene expression in liver, submandibular gland and kidney was significantly advanced in L-Ornithine treated mice. METHODS: To investigate the effect of L-Ornithine on sleep behavior, L-Ornithine was added to the diet of maternal mice, and its effect on the sleep behavior of offspring mice was observed. RESULTS: L-Ornithine supplementation increased sleep-like behavior in mice. METHODS: To study the effect of L-Ornithine on acute necrotizing pancreatitis, rats were intraperitoneally injected with L-Ornithine (3 g/kg). RESULTS: Severe acute necrotizing pancreatitis was induced by L-Ornithine in rats.
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• In Vitro:
  METHODS: HK-2 cells were treated with L-Ornithine (100, 300 μM) for 24 hours, and ROS levels were measured using fluorescence microscopy. RESULTS: Ornithine protected HK-2 cells from ROS production.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amino Acids and Derivatives, AminoAcidsandDerivatives, Arginase-1, Arginase-2, (S)-2,5-Diaminopentanoic acid, 2,5-Diaminopentanoic acid, Ornithine aminotransferase, Ornithine carbamoyltransferase, Ornithine decarboxylase antizyme 1, inhibit, L Ornithine, LOrnithine, L-Ornithine, Inhibitor, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

6262