Kahweol

SKU: orb1297313

Description

Kahweol is a bioactive diterpene with demonstrated anticarcinogenic, anti-angiogenic, and anti-inflammatory properties. It functions by inhibiting NF-κB activation, specifically by blocking IκB degradation and IκB kinase activity, as shown in LPS-stimulated cellular models. This compound is a valuable research tool for studying inflammation and cancer pathways in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 6894-43-5
• MW: 314.42
• Purity: 99.86% (May vary between batches)
• Formula: C₂₀H₂₆O₃
• SMILES: C[C@]12[C@]3([C@]4(C[C@]([C@](CO)(O)C4)(CC3)[H])CC[C@@]1(C5=C(C=C2)OC=C5)[H])[H]
• Target: NF-κB,Apoptosis,AMPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.18 mM);DMSO:27.5 mg/mL (87.46 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Kahweol, inhibit, NFkB, NFκB, NF-kB, NF-ΚB, IKK, Apoptosis, AMPK, AMP-activated protein kinase, P450

Compound Identifiers

PubChem CID

114778