HG-14-10-04

SKU: orb1303304

Description

HG-14-10-04 is a highly selective small molecule inhibitor targeting the anaplastic lymphoma kinase (ALK). It is a valuable research tool for investigating ALK-driven pathologies, such as certain cancers, in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1356962-34-9
• MW: 532.08
• Purity: >99.99% (May vary between batches)
• Formula: C₂₉H₃₄ClN₇O
• SMILES: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(CC1)N1CCN(C)CC1
• Target: ALK,EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.88 mM);DMSO:5.33 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  EGFR 19del/TM/CS:22.6 nM|ALK:20 nM|EGFR (L858R/T790M/C797S):124.5 nM|EGFR (L858R/T790M):15.6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD246, Cluster of differentiation 246, ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, anticancer, inhibit, Inhibitor, HG 14 10 04, HG141004, HG-14-10-04, HER1, Epidermal growth factor receptor, ErbB-1, EGFR

Compound Identifiers

PubChem CID

56655374