Halofuginone HBr

SKU: orb1304120

Description

Halofuginone hydrobromide is a semisynthetic alkaloid that suppresses collagen type I and MMP-2 gene expression. This inhibition of key fibrotic and angiogenic promoters makes it a valuable research tool for studying fibroproliferative diseases, tumor stroma, and cancer progression in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 64924-67-0
• MW: 495.6
• Purity: > 95%
• Formula: C₁₆H₁₇BrClN₃O₃ • HBr
• SMILES: Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
• Target: Sodium Channel,Parasite,TGF-beta/Smad,Calcium Channel,DNA/RNA Synthesis
• Solubility: Soluble in DMSO (up to 50 mg/ml)

Bioactivity

• Target IC50:
  Prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 713205

Compound Identifiers

PubChem CID

11591339