GW-441756

SKU: orb1301117

Description

GW 441756 is a potent and selective small molecule inhibitor of the Tropomyosin-related kinase A (TrkA) receptor, exhibiting an IC50 of 2 nM. It is widely used in biochemical and cellular research to investigate TrkA signaling pathways in both in vitro and in vivo models of neurobiology and oncology.

Research Area

Neuroscience

Key Properties

• CAS Number: 504433-23-2
• MW: 275.31
• Purity: >98%
• Formula: C₁₇H₁₃N₃O
• SMILES: Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12
• Target: Kinase
• Solubility: Soluble in DMSO (up to 5 mg/ml).

Bioactivity

• Target IC50:
  TrkA:2 nM
• In Vivo:
  GW441756 inhibits γH2AX production mediated by TrkA and apoptosis in cells overexpressing TrkA. It specifically blocks TrkA-induced cell death in a dose-dependent manner.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tyrosine, Trkreceptor, TrkA, Trk Receptor, Trk receptor, Tropomyosin related kinase receptor, specific, receptor, potent, factor, growth, GW 441756, GW441756, GW-441756, Inhibitor, kinases, inhibit, NGF, nerve, Apoptosis, CDK2, C-Raf-1

Compound Identifiers

PubChem CID

9943465