Go6976

SKU: orb1741480

Description

Go6976

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 136194-77-9
• MW: 378.43
• Purity: 98.13% (May vary between batches)
• Formula: C₂₄H₁₈N₄O
• SMILES: Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
• Target: Influenza Virus,PKC
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (8.72 mM);DMSO:30 mg/mL (79.27 mM)

Bioactivity

• Target IC50:
  PKCβ1:6.2 nM|PKC:7.9 nM|PKC:20 nM|PKCα:2.3 nM
• In Vitro:
  30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gö 6976, Go6976, PKC

Compound Identifiers

PubChem CID

3501