Glycopyrrolate

SKU: orb1305554

Description

Glycopyrrolate

Research Area

Neuroscience

Key Properties

• CAS Number: 596-51-0
• MW: 398.33
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₂₈BrNO₃
• SMILES: [Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C1CCCC1)C1=CC=CC=C1
• Target: AChR
• Solubility: DMSO:50 mg/mL (125.52 mM);Ethanol:55 mg/mL (138.08 mM);H2O:72 mg/mL (180.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM)

Bioactivity

• In Vitro:
  Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6 nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Robinul, Glycopyrrolate bromide, Glycopyrronium, Glycopyrronium bromide, Gastrodyn, mAChR, mAChR M1

Compound Identifiers

PubChem CID

11693