Ganodermanondiol

SKU: orb1684585

Description

Ganodermanondiol is a small molecule inhibitor of melanogenesis that suppresses key proteins (tyrosinase, TRP-1, TRP-2, MITF) and modulates MAPK/cAMP pathways in B16F10 cells. It also demonstrates anti-inflammatory and hepatoprotective properties via Nrf2/HO-1 and AMPK activation, supporting research in dermatology and liver disease models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 107900-76-5
• MW: 456.7
• Purity: 99.24% (May vary between batches)
• Formula: C₃₀H₄₈O₃
• SMILES: C[C@@]12C=3C([C@@]4(C)[C@](C)(CC3)[C@@]([C@@H](CC[C@@H](C(C)(C)O)O)C)(CC4)[H])=CC[C@]1(C(C)(C)C(=O)CC2)[H]
• Target: Autophagy,cAMP,Tyrosinase,TRP/TRPV Channel,AMPK,Melanocortin Receptor,Immunology/Inflammation related,MAPK

Bioactivity

• Target IC50:
  HIV-1 protease:90μM
• In Vitro:
  Ganodermanondiol significantly increased the survival rate of HepG2 cells and inhibited t-BHP-induced ROS generation at non-cytotoxic concentrations (5, 10, 20, 40 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, Nrf2, Ganodermanondiol, HIV Protease, HIV

Compound Identifiers

PubChem CID

73294