Gabazine

SKU: orb1299651

Description

Gabazine (SR95531) is a selective and competitive GABAA receptor antagonist with a Ki in the nanomolar range (74-150 nM). It is widely used in neuroscience research to study GABAergic neurotransmission, synaptic inhibition, and related neurological disorders in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 104104-50-9
• MW: 368.23
• Purity: 99.24% (May vary between batches)
• Formula: C₁₅H₁₈BrN₃O₃
• SMILES: Br.COc1ccc(cc1)-c1ccc(=N)n(CCCC(O)=O)n1
• Target: GABA Receptor
• Solubility: DMSO:75 mg/mL (203.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM)

Bioactivity

• Target IC50:
  GABAA:74-150 nM(ki)
• In Vivo:
  Gabazine is effective against GABAA receptor isoforms from mice, rats, and humans.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, GABA Receptor, GABAA, GABAReceptor, Gabazine, Gamma-aminobutyric acid Receptor, γ-Aminobutyric acid Receptor, SR 95531, SR95531, SR-95531

Compound Identifiers

PubChem CID

107895