FR 122047

SKU: orb1305810

Description

FR 122047 hydrochloride is a potent and selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting an IC50 of 28 nM for human recombinant COX-1 versus 65 µM for COX-2. This small molecule is a valuable research tool for investigating COX-1-specific roles in physiological and pathophysiological processes, including platelet aggregation and gastric function, in both in vitro and ex vivo experimental models.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 130717-51-0
• MW: 459.99
• Purity: 99.93% (May vary between batches)
• Formula: C₂₃H₂₆ClN₃O₃S
• SMILES: CN1CCN(CC1)C(=O)C2=NC(=C(S2)C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC.Cl
• Target: COX
• Solubility: DMSO:4 mg/mL (8.7 mM);H2O:2 mg/mL (4.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.17 mM)

Bioactivity

• Target IC50:
  COX-2:65 µM|COX-1:28 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FR 122047, FR 122047 hydrochloride, FR122047, FR-122047, inhibit, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, COX, COX-2, COX-1, Cyclooxygenase

Compound Identifiers

PubChem CID

196840