Fondaparinux sodium

SKU: orb1303188

Description

Fondaparinux sodium is a synthetic antithrombin-mediated selective factor Xa inhibitor. It is widely used in preclinical research to study thrombosis and hemostasis, serving as a key tool in both in vitro coagulation assays and in vivo models of venous thromboembolism.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 114870-03-0
• MW: 1728.08
• Purity: >99.99% (May vary between batches)
• Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈
• SMILES: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C([O-])=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
• Target: Factor Xa
• Solubility: H2O:17.36 mM;DMSO:60 mg/mL (34.72 mM)

Bioactivity

• In Vivo:
  Fondaparinux sodium exhibits a linear, dose-dependent pharmacokinetic profile ensuring a highly predictable response. It is fully bioavailable (100%), with a quick onset and a half-life of 14 to 16 hours, providing prolonged antithrombotic effects throughout a 24-hour period. Notably, the drug does not impact prothrombin time, activated partial thromboplastin time, or platelet function and aggregation.
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• In Vitro:
  Fondaparinux sodium, the pioneering agent in a novel class of anticoagulants, selectively targets factor Xa with IC50 values (anti-Xa IU/ml) of 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Arixtra, Natural heparin pentasaccharide Sodium, inhibit, Fondaparin, Fondaparin sodium, Fondaparinux, Fondaparinux sodium, FactorXa, Factor Xa, Fxa, Inhibitor, SR-90107A

Compound Identifiers

PubChem CID

636380