Flubendazole

SKU: orb1311032

Description

Flubendazole

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 31430-15-6
• MW: 313.2832
• Purity: 99.67% (May vary between batches)
• Formula: C₁₆H₁₂FN₃O₃
• SMILES: COC(=O)NC1=NC2=C(N1)C=CC(=C2)C(=O)C1=CC=C(F)C=C1
• Target: STAT,Microtubule Associated,MDM-2/p53,Parasite,Apoptosis,Autophagy
• Solubility: DMSO:9 mg/mL (28.73 mM)

Bioactivity

• In Vivo:
  Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes.
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• In Vitro:
  Flubendazole results in morphological changes included contraction of the soma region, the formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. Flubendazole has a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). Flubendazole and Albendazole show similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, NSC 313680, Parasite, NSC313680, NSC-313680, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, microtubule, Fluvermal, Flubendazole, Flumoxanal, Flumoxane, Apoptosis

Compound Identifiers

PubChem CID

35802