FLT3/HDAC-IN-3

SKU: orb3210426

Description

FLT3/HDAC-IN-3 is a dual inhibitor targeting both FLT3 and HDAC. It shows potent inhibition of FLT3 (IC50 = 14 nM), HDAC1 (IC50 = 27 nM), HDAC6 (IC50 = 20 nM), and FLT3D853Y (IC50 = 55 nM), while exhibiting weak activity against HDAC8 and no activity against HDAC4. The compound is characterized by kinase selectivity, plasma stability, and stability in human liver microsomes. It demonstrates antiproliferative effects in various hematologic malignancy cell lines. In the Jeko-1 xenograft model, FLT3/HDAC-IN-3 exhibits inhibitory effects with no significant toxicity observed, making it useful for research in hematologic malignancies.

Key Properties

• CAS Number: 2864394-30-7
• MW: 445.53
• Formula: C₂₂H₃₂FN₇O₂
• SMILES: O=C(NO)CCCCCCNC1=NC(=NC=C1F)NC2=CC=C(C=C2)N3CCN(C)CC3
• Target: Apoptosis,HDAC,FLT,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,HDAC,FLT,ROS