Fidaxomicin

SKU: orb1223774

Description

Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial Infection Approved(In Vitro):Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024 μg/mL).(In Vivo):Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 873857-62-6
• MW: 1058.039
• Purity: >98% (HPLC)
• Formula: C₅₂H₇₄Cl₂O₁₈
• SMILES: O=C(O[C@@H]1[C@@H](C)O[C@@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)/C(C)=C/C(C)=C/C[C@@H]([C@H](O)C)OC2=O)[C@@H](OC)[C@H]1O)C4=C(O)C(Cl)=C(O)C(Cl)=C4CC
• Target: Antibacterial
• Solubility: DMSO: ≥ 33 mg/mL

Bioactivity

• In Vivo:
  Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis. Animal model: Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis). Dosage: 0.2, 1, and 5 mg/kg. Administration: Orally, once a day for 5 days, beginning 8 h after infection. Result: Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.
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• In Vitro:
  Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024 μg/mL).
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OPT-80 | PAR-101

Quick Database Links

Gene Symbol

Antibacterial

Wei Lin, Kalyan Das, David Degen, Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard Y. Ebright, Elena Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, Zhening Zhang, Edward T. Eng, Dennis Thomas, Stefano Donadio, Haibo Zhang, Changsheng Zhang, Achillefs N. Kapanidis, Richard H. Ebright Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) Molecular Cell, 70, 60 (2018)

PubMed: 29606590

Applications

Activity Assay, In vitro

Reactivity

Bacteria