Exo1

SKU: orb1302713

Description

Exo1 is a small molecule compound that selectively blocks the exocytic transport pathway. It is utilized in cell biology research to study protein secretion, membrane trafficking, and cellular communication in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 75541-83-2
• MW: 273.26
• Purity: 99.56% (May vary between batches)
• Formula: C₁₅H₁₂FNO₃
• SMILES: COC(=O)c1ccccc1NC(=O)c1ccc(F)cc1
• Target: GTPase,Others
• Solubility: DMSO:22.5 mg/mL (82.34 mM);10% DMSO+90% Corn Oil:2 mg/mL (7.32 mM)

Bioactivity

• In Vitro:
  Exo1 functions as a modifier of Golgi ARF1 GTPase activity, offering a unique approach to modulate Golgi function. Unlike agents like BFA, Exo1 targets a specific subset of membrane processes associated with the Golgi, presumably interacting with a different protein target, which could lead to distinct side effects. It disrupts vesicular traffic between the Endoplasmic Reticulum (ER) and the Golgi apparatus by altering Golgi structures, effectively inhibiting exocytosis with an IC50 value of approximately 20 μM. Furthermore, Exo1 impedes the acquisition of endoglycosidase H resistance in newly synthesized proteins, including VSVGts-GFP, transferrin, and MHC class I, indicative of its role in the intricate regulation of protein trafficking and modification.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Exo 1, Exo-1, Exo1, exocytic pathway, inhibit

Compound Identifiers

PubChem CID

310557