Endothelin Receptor Antibody

SKU: orb3032073

Description

Getagozumab is a humanized IgG4-kappa monoclonal antibody that specifically targets endothelin receptor type A (EDNRA) with potent antagonistic activity. Getagozumab significantly lowered pulmonary arterial pressure in both hypoxia-induced and monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) monkey models and further attenuated the associated pulmonary arterial and right ventricular hypertrophy.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: Endothelin Receptor
• Molecular Weight: 145.28 kDa
• Purity: 98.90% (May vary between batches)
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Concentration: 5.49 mg/mL
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Patecibart, GMA301, GMA-301

Quick Database Links

Gene Symbol

Endothelin Receptor