Dronedarone hydrochloride

SKU: orb1309854

Description

Dronedarone hydrochloride (SR33589) is a structural analog of amiodarone developed for atrial fibrillation research. It functions as a multi-channel blocker, enabling in vitro electrophysiology studies and in vivo models of cardiac arrhythmia to investigate its mechanisms and therapeutic potential.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 141625-93-6
• MW: 593.22
• Purity: 99.91% (May vary between batches)
• Formula: C₃₁H₄₄N₂O₅S·HCl
• SMILES: Cl.CS(=O)(=O)Nc1cc2c(c(oc2cc1)CCCC)C(=O)c1ccc(cc1)OCCCN(CCCC)CCCC
• Target: Autophagy,Potassium Channel,Calcium Channel,Adrenergic Receptor,Sodium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:38 mg/mL (64.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.37 mM);DMSO:60 mg/mL (101.14 mM)

Bioactivity

• In Vivo:
  Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction.
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• In Vitro:
  Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium Channel, Autophagy, Adrenergic Receptor, AdrenergicReceptor, Dronedarone, Dronedarone HCl, Dronedarone hydrochloride, Dronedarone Hydrochloride, CalciumChannel, Inhibitor, KcsA, inhibit, SodiumChannel, Sodium Channel, SR 33589, SR33589, SR-33589, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

219025