DPN

SKU: orb1299631

Description

DPN (Diarylpropionitrile) is a selective ERβ agonist used to investigate the distinct roles of estrogen receptor subtypes. It is a valuable research tool for in vitro and in vivo studies in neuroscience, endocrinology, and oncology, particularly for exploring ERβ-mediated pathways in inflammation, neuroprotection, and cancer.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 1428-67-7
• MW: 239.27
• Purity: >98%
• Formula: C₁₅H₁₃NO₂
• SMILES: Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Bioactivity

• Target IC50:
  ERβ:0.85 nM (EC50)
• In Vitro:
  DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diarylpropionitrile

Compound Identifiers

PubChem CID

102614