Diphenhydramine hydrochloride

SKU: orb1310716

Description

Diphenhydramine hydrochloride

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 147-24-0
• MW: 291.816
• Purity: 99.89% (May vary between batches)
• Formula: C₁₇H₂₂ClNO
• SMILES: Cl.CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
• Target: Apoptosis,Endogenous Metabolite,Antibacterial,Histamine Receptor
• Solubility: DMSO:45 mg/mL (154.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.85 mM)

Bioactivity

• In Vitro:
  Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents. Diphenhydramine causes a shift of the steady-state inactivation curve for both types of sodium currents in the hyperpolarizing direction. Diphenhydramine produces a profound use-dependent block when the cells are repeatedly stimulated with high-frequency depolarizing pulses. Diphenhydramine induces apoptosis in a dose- and time-dependent manner in both CCRF-CEM and Jurkat cell lines, whereas Cimetidine fails to induce significant effects at similar concentrations. Diphenhydramine-induced apoptosis is evaluated in terms of morphology, flow cytometry, and the release of cytochrome c to the cytosol. Diphenhydramine inhibits cell proliferation without inducing apoptosis in human peripheral blood mononuclear cells. Diphenhydramine (500 nM) significantly reduces the baseline firing of the periaqueductal gray neurons without a significant effect on the frequency of postsynaptic potentials. Diphenhydramine at high concentration inhibits periaqueductal gray neurons, but at low concentrations it has no effect on the baseline-firing rate and it blocks the response to neurotensin and tomedial preoptic nucleus stimulation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DPH, Diphenhydramine, Diphenhydramine HCl, Diphenhydramine hydrochloride, Diphenhydramine Hydrochloride, Inhibitor, inhibit, H1 receptor, Endogenous Metabolite, HistamineReceptor, Histamine Receptor

Compound Identifiers

PubChem CID

8980