Digitoxin

SKU: orb1310748

Description

Digitoxin is a potent Na+/K+-ATPase inhibitor with an EC50 of 0.78 µM. This cardenolide is widely used in cardiovascular research to study ion transport mechanisms and has been employed in both in vitro assays and in vivo models of heart failure.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 71-63-6
• MW: 764.94
• Purity: 99.84% (May vary between batches)
• Formula: C₄₁H₆₄O₁₃
• SMILES: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4CC[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C
• Target: Calcium Channel,ATPase,Bcl-2 Family,HSV,Apoptosis,Caspase
• Solubility: DMSO:100 mg/mL (130.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.23 mM)

Bioactivity

• Target IC50:
  Na+, K+-ATPase:0.78 μM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Digitoxin, Digitoxinum, Digitoxoside, inhibit, Na+/K+ ATPase, Na+/K+-ATPase, organic anion transporter, Inhibitor, Unidigin, Sodium potassium pump

Compound Identifiers

PubChem CID

441207