Darunavir Ethanolate

SKU: orb1304312

Description

Darunavir Ethanolate is a potent HIV-1 protease inhibitor used in antiretroviral therapy. To combat drug resistance, it is co-administered with other antiretroviral agents. Its mechanism and efficacy are studied in both in vitro antiviral assays and in vivo models of HIV infection.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 635728-49-3
• MW: 593.74
• Purity: 99.86% (May vary between batches)
• Formula: C₂₉H₄₃N₃O₈S
• SMILES: CCO.[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(N)cc1
• Target: HIV Protease
• Solubility: DMSO:93 mg/mL (156.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.56 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HIV-1 protease:1 nM (Ki)
• In Vivo:
  Darunavir effectively combats both wild-type and protease inhibitor (PI)-resistant HIV strains, boasting an oral bioavailability of 37%. Its efficacy is significantly enhanced when used in conjunction with ritonavir, which raises its bioavailability to 82%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human immunodeficiency virus, HIVProtease, HIV Protease, HIV, inhibit, Inhibitor, Darunavir Ethanolate, Darunavir, Darunavir Ethanolate, TMC 114, TMC114, TMC-114, WT HIV-1 protease, UIC94017, UIC-94017, UIC 94017

Compound Identifiers

PubChem CID

23725083