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DAPT

SKU: orb1225711

Description

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

Images & Validation

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Key Properties

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CAS Number208255-80-5
MW432.46
Purity>98% (HPLC)
FormulaC23H26F2N2O4
SMILESO=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O
TargetGamma-secretase
SolubilityEthanol: 50 mg/mL (115.61 mM); DMSO: 86 mg/mL (198.86 mM)

Bioactivity

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In Vitro
DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts. DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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GSI-IX

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Protocol Information

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