Daminozide

SKU: orb1226076

Description

Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.(In Vitro):Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases).(In Vivo):Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.

Key Properties

• CAS Number: 1596-84-5
• MW: 160.17
• Purity: >98% (HPLC)
• Formula: C₆H₁₂N₂O₃
• SMILES: OC(CCC(NN(C)C)=O)=O
• Target: Histone Demethylase
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.
• In Vitro:
  Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50 = 127 μM for KDM3A, or greater against other demethylases).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alar | Aminozide | B 995 | DIMG | DMASA | Kylar | SADH | Succinic Acid

Quick Database Links

Gene Symbol

Histone Demethylase