(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)

SKU: orb3053989

Description

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.

Research Area

Cell Biology

Key Properties

• CAS Number: 118102-98-0
• MW: 3625.25
• Purity: >98% (HPLC)
• Formula: C₁₆₅H₂₅₁N₄₉O₄₀S₂
• Solubility: H2O : 100 mg/mL (27.58 mM; ultraphonic)

Bioactivity

• In Vivo:
  (D-Trp12, Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i. v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung.
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• In Vitro:
  (D-Trp12, Tyr34)-pTH (7-34) amide (0.05-10 μM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells. (D-Trp12, Tyr34)-pTH (7-34) amide (0.1-10 μM) attenuates inhibition of NapiT promoted by 1 nM of either PTHrP or PTH.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only