D-Glutamic acid

SKU: orb1217727

Description

D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6893-26-1
• MW: 147.13
• Purity: >98% (HPLC)
• Formula: C₅H₉NO₄
• SMILES: N[C@H](CCC(O)=O)C(O)=O
• Target: Endogenous Metabolite
• Solubility: H2O:10 mg/mL (67.97 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D-and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid.
  Read more...
• In Vitro:
  Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-Glutamic acid

Quick Database Links

Gene Symbol

Endogenous Metabolite